The SZ-100 nanopartica series instruments are flexible analytical tools for characterizing the physical properties of small particles.
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The SZ-100 nanopartica series instruments are flexible analytical tools for characterizing the physical properties of small particles. Depending on the configuration and application the system can be used as a particle size analyzer, or also used to measure zeta potential, molecular weight, (MW) and second virial coefficient (A2). Typical applications for the SZ-100 include nanoparticles, colloids, emulsions, and submicron suspensions.
Particle size analysis is performed by dynamic light scattering (DLS). Depending on the physical properties of the sample, the dynamic range is 0.3 nm – 8 µm. The lower limit is influenced by concentration, how strongly the sample scatters light, and the presence of large, unwanted particles. The upper limit is influenced by the density of the sample since DLS is modeled on all motion coming from Brownian motion, not gravitational settling.
The charge on the surface of particles is characterized by the SZ-100 by measuring the zeta potential of a suspension. The sample is injected into a disposable cell and a measurement of the particle electrophoretic mobility results in the calculated zeta potential. The zeta potential of the sample is most often used as an indicator of dispersion stability. Large magnitude zeta potential values indicate that an electrostatically stabilized suspension will remain stable. The zeta potential is often measured as a function of pH or other change in the chemistry to help formulators create new products with a long shelf life. Conversely identifying conditions at which the zeta potential is zero (that is, the sample is at the isoelectric point) allows one to choose optimum conditions for flocculating and separating particles.
The same instrument can also be used to measure the molecular weight and second virial coefficient of proteins, polymers, and other molecules. The user prepares several solutions with known concentrations and then uses the system in a static light scattering mode to create a Debye plot, which results in a calculation of both MW and A2.
Particle size: Dynamic Light Scattering (DLS) technique
Measurement range
Particle diameter: 0.3nm-8.0μm
Measurement Accuracy
Particle size: ISO 13321/22412 compliant.
NIST traceable polystyrene latex particle standard: 100nm measurement accuracy = +/- 2%
Measurement time
Approx. 2 minutes in general for particle size analysis
Sampling cell
Cuvette cell
Sampling volume
12μl ～ 4ml* (* The sampling volume depends on the cell volume capacity.)
Zeta potential: Laser doppler electrophoresis technique
Measurement range
-200 – +200mV
Measurement time
Approx. 2 minutes in general
Sampling cell
Dedicated disposable cell or dip cell
Sampling volume
~100μl for disposable cell
Molecular weight: Static light scattering Debye plot technique
Measurement Range
Mw: 1×103 – 2×107 g/mol
Sampling cell
Cuvette cell
Physical
Power supply: AC 100-240V, 50/60Hz, 150VA
Laser: DPSS 532 nm, 10 mW Class I
Interface: USB 2.0, between the analyzer and PC
External dimensions: 385(D) ´ 528(W) ´ 273(H) mm (Except for projections)
Mass approx: 25kg
Temp control range: 1-90℃ for particle size, 1-70℃ for zeta potential
Operating temp and humidity: 15-35℃, Relative humidity = 85% or less, no condensation
Condensation control: Purge port connection available.
