Mouse and Rat Tail Blood Pressure(MRBP)

IITC has once again designed a first for laboratory research equipment a true turn-key system when it is key critical for determing accurate, consistent blood pressure on mice, rats or any other laboratory animal test subject.

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A revolutionary design bringing non-invasive blood pressure testing to another level.

IITC the true “Gold Standard” and still World Leader in mouse and rat tail cuff blood pressure measuring systems.

IITC has once again designed a first for laboratory research equipment a true turn-key system when it is key critical for determing accurate, consistent blood pressure on mice, rats or any other laboratory animal test subject.

A true, compact, simple yet versatile system that can test from a single up to 200 animals at a time with independent control of each channel.

Simple daisy-chaining of systems allow expansion of systems, up to 200 independently, controlled systems. No other system in the world has such vast capabilities as the IITC blood pressure systems.

These new mouse and/or rat blood pressure systems have all components now built into 1 small unit. Controls, inflation off tail cuff, built-in warming environment with whisper quiet fans has finally been designed to allow you the user an ideal system for teaching facilities and for the pharmaceutical industry when high through-put is a must.

Single animal systems are controlled from the touch screen which allows keying in all necessary test setups.

Temperature of internal environment – we suggest 34 deg. C for mice/ 32 deg. C for rats but can be set lower.

Methodology is still the only low temperature “validated” tail cuff method that is world reknowned for accuracy for 37 years.

Touch screen control allows ease of operation supplying automatic evaluation of test results – systolic, diastolic, mean and heart rate.

No need for pulse calibration of the systems, analog outputs standard for both pulse and pressure.

Data is collected, stored, displayed and can be transferred to the supplied memory stick. USB allows for software control for multi channel systems and for single animal systems software is supplied enabling users to view and export data collected.

A minimum of 36 recordings per channel can be stored per channel/system.

Reports are internal in an Excel style format, simple migration of data.

Our systems DO NOT require to have computers purchased or the IITC software, we are compatible with most data collection software on the market. The analog output allows users to interface their existing data collection software with our blood pressure systems when existing software exists.

When studies call for an MRI setting these systems can still be used due to the independent design. Tail cu¬s can be in any setting and are not required to be connected directly to the electronics at any time. IITC supplies extended test cable lengths of the sensors when MRI testing is to be performed.

Cleaning of systems are an ease, removable trays are supplied standard with each system when needed.

Mouse rat tail cuff blood pressure system components

Tail Cuff Plethysmography for Mouse Rat for Blood Pressure

The IITC tail cuff’s have the ability to detect mouse tail cuff blood pressure or rat tail cuff blood pressure via the tail photoelectrically. The photoelectric sensor, light source and sensor are built into a one unit which attaches to any one of the IITC restrainers with nylon hand screws. All the sensors are nonmagnetic. They are extremely sensitive in detecting pulses due to IITC’s superior design and knowledge of mouse and rat blood pressure measurements. The ambient temperature that a reading can be taken starts at 30 degrees c. The maximum temperature needed for a test is usually 32 degrees c. for rats and 34 degrees c. for mice. The systolic readings are within five mmHg of Cannulation and Telemetry. (Validated)

Part #

Description

B64-1”

Sensor, 650-800 grams

B63-3/4”

Sensor, 500-650 grams

B60-7/16”

Sensor, 150-400 grams

B60-3/8”

Sensor, 70-160 grams

B60-1/4”

Sensor, 20-80 grams

IITC Life Science is the ONLY company capable ofmeasuring blood pressure on all of the below animals.

Part #

Description

5OR

O-Ring 1/4” – 50/pack

5MOR

O-Ring 3/8” – 50/pack

5EOR

O-Ring 7/16” – 50/pack

5FOR

O-Ring 3/4” – 50/pack

5SOR

O-Ring 1” – 50/pack

2ACL

Cuff liner 1/4” – 100/pack

2CCL

Cuff liner 3/8” – 100/pack

2CL

Cuff liner 7/16” – 100/pack

2BCL

Cuff liner 3/4” – 100/pack

2DCL

Cuff liner 1” – 100/pack

 

 

Rodent Restrainers for mice and rats

IITC rodent restrainers are used with the noninvasive blood pressure tail cuff method systems for mice and rats they can also be used for tail vein injections or other studies where the animal needs to be restrained.

NEW – Extra large mouse restrainer 45 to 70 grams

IITC carries rodent restrainers in eight different sizes; the weight range is from neonate rats and adult mice up to 1,000 gram rats. They are constructed of sturdy clear, 1/4” wall acrylic. Only a mild soap and water solution is to be used to clean the restrainers no ammonia based products should be used.
They are all supplied with an adjustable head gate and the end plate is removable by snaps. This allows the animal to “walk-in” as opposed to the traditional method of bootstrap holders where the animal is physically forced into the restrainer backwards. The backward forcing of animals may cause severe trauma.

Head gate, end plate, and snaps can be purchased separately.

Part #

Description

Size

Dimensions

84

Rodent Restrainer Adult mice and neonate rats

20 to 45 grams

1” ID (25 mm) – 4” Length
84XLRodent Restrainer45 to 70 grams1 1/4″ ID (30 mm) – 5″ Length

83

Rodent Restrainer

70 to 170 grams

1 1/2” ID (38 mm) – 6” Length

82

Rodent Restrainer

180 to 270 grams

2” ID (50 mm) – 8” Length

81

Restrainer Rodents

250 to 400 grams

2 1/2” ID (63 mm) – 9” Length

80

Restrainer Rodents

400 to 600 grams

3” ID (75 mm) – 12” Length

79

Restrainer Rodents

600 to 800 grams

3 1/2” ID (88 mm) – 13” Length

78

Restrainer Rodents

750 to 1000 gram

4” ID (105 mm) – 13” Length

Blood Pressure Data Acquistion Software

IITC software record’s analyze’s and reports the data from any of the IITC amplifiers for blood pressure studies. The final data is sent from the amplifier to the software program. The end-point selection is automatic for Systolic, Mean, Heart Rate while the Diastolic values are automatically computed. The user is always in control to override the automatic process by the click of a mouse. Data can be saved, ignored or deleted at the operator’s discretion. Any test can be recalled, displayed, printed and modified as needed

The software supplies ID number, Animal number, test number, date, time, Systolic, Mean, Diastolic and heart rate and Calibration is a breeze. Software can be used with manual, semi-automatic or fully automatic noninvasive blood pressure systems.

Features
Record, report and analyze data
Two channel recording capabilities
Report data can be imported to Excel
Test data recorded, displayed in real-time
Automatic evaluation of captured data

Our software has IITC built-in artifact filter and has user select frequency range’s. A detailed report can be printed or imported into a spreadsheet at the end of a test. Software and analog to digital converter supplied. Software can control the cuff pump #20-NW and recognizes the animals number from the Scanner #65-12.

System Requirements:

Windows 98 or higher, serial port.

Demo disc available upon request.

One year warranty
120/240V

Part #

Description

31

Noninvasive Blood Pressure Software

Single and Dual Channel Chart Recorder

The IITC 38L Single Channel chart recorder as well as the 45L dual channel recorder are ideal instruments for use in recording Noninvasive blood pressure in laboratory animals with of these systems. They also have a wide range of uses in the research, development and education departments as well.
The “Plot” and “Home” function can set the pen back to the start for comparative measurements. The pen starts from exactly the same point of the chart in a repetitive form.

Specifications:

  • 14 calibrated steps imv.
  • 20V variable range: 40 to 100 % FS.
  • Input impedance 1M Ohm
  • Common mode rejection 130 dB
  • Zero adjustment: -50 150% FS
  • Zero suppression: 6 calibrated steps
  • Chart speeds: 0.1/0.2/0/5/1/2/5/10/20 mm/min. & mm/sec
  • Paper 25m roll (80 ft.)
  • External input: TTL level
  • 110/220 switch selectable
  • Maximum input signal: 42VDC
  • Power Consumption: 30VA on single channel, 50 VA on dual channel
  • Matches CSA & VDE.

Part #

Description

38L

Single Channel Chart Recorder

45L

Dual Channel Chart Recorder

Amplifier with automatic cuff inflation

The IITC amplifier with built in cuff inflation pump is used for mouse rat blood pressure studies. The method is done noninvasive via the tail cuff method.

The IITC method requires minimal warming of rats and mice. The rodents should be warmed to an ambient temperature of 30 deg. c. for rats and 32 deg. c. for mice, which is well below the thermostress level (see NIBP Intro. page). It is suggested to use one of the IITC warming chambers. The artifact filter eliminates the breathing and movement artifacts, enabling the user to pick out endpoints easily. In addition the amplifier has a built in cuff pump which allows for automatic cuff inflation. The built-in cuff pump has adjustable cuff pressure limits with automatic cut off, remote trigger capability, adjustable deflation rate, a manual air release for an immediate pressure drop and a test termination pressure control allows for quick 10 to 15 second test cycles.
Features:

  • Validated data:
  • Telemetry
  • Direct blood pressure

Data supplied:

  • Systolic
  • Mean
  • Diastolic
  • Heart Rate
  • Lowest temperature method

Indirect heating

MRI systems available

Animal color not a factor

USB Optional

RS232 Standard
Animals:

  • Mice
  • Rats
  • Cats
  • Dogs
  • Rabbits
  • Swine
  • Monkeys
  • Lifetime Warranty

Analog output. The instrument has separate outputs for single channel and dual channel (superimposed and split) recording. The typical pulse amplitude is 100 mV to 1 V. The pressure amplitude is adjustable from one to five volts at 300 mmHg. If systolic and heart rate are desired, a single channel chart recorder #38L is sufficient; if the Mean and Diastolic are the desired reading then a dual channel chart recorder is recommended #45L or the IITC software package #31.

The unit can be used in any one of the IITC multi-channel systems.

Lifetime Warranty on amplifier
One year warranty on internal cuff pump.
120/240V

Part #

Description

229

Amplifier with automatic cuff inflation

Rat and Mouse Blood Pressure Amplifier, Manual Inflation

The IITC Life Science amplifier with manual inflation allows testing of a single animal at a time when measuring rat and/or mouse blood pressure. A noninvasive tail cuff method that is economical, validated and accurate.

The IITC Life Science method requires minimal warming of rats and mice. The rodents should be warmed to an ambient temperature of 30 deg. c. for rats and 32 deg. c. for mice, which is well below the thermostress level (see NIBP Intro. page). It is suggested to use one of the IITC warming chambers.
Validated data:

  • Telemetry
  • Direct blood pressure

Data supplied:

  • Systolic
  • Mean
  • Diastolic
  • Heart Rate
  • Lowest temperature method

Indirect heating

MRI systems available

Animal color not a factor

USB Optional

RS232 Standard
Animals:

  • Mice
  • Rats
  • Cats
  • Dogs
  • Rabbits
  • Swine
  • Monkeys

Lifetime Warranty

A unique feature of IITC’s amplifier is the artifact filter, which minimizes the breathing and movement artifacts, enabling the user to pick out the endpoints easily.

Analog output. The instrument has separate outputs for single channel and dual channel (superimposed and split) recording. The typical pulse amplitude is 100 mV to 1 V. The pressure amplitude is adjustable from one to five volts at 300 mmHg. If systolic and heart rate are desired, a single channel chart recorder #38L is sufficient. If the Mean and Diastolic are the desired reading then a dual channel chart recorder is recommended #45L or the IITC software package #31.

These units can be used in a manual, automatic, single, or multi-channel system.

Lifetime Warranty
120/240V

Part #

Description

29

Amplifier-Manual Inflation

Automatic Cuff Pump for Rat and Mouse Blood Pressure

The IITC automatic inflation cuff pump is a dedicated cuff pump for small animal noninvasive blood pressure testing. This cuff pump replaces manual inflation and can be used with all of IITC’s indirect blood pressure test systems.

The IITC cuff pump has an adjustable cut-off pressure in 50 mmHg increments, adjustable deflation rate calibrated in mmHg and test termination pressure. The maximum pressure is 300 mmHg and higher. The test termination pressure feature allows the tests to be performed in 10-15 seconds. Single or repetitive cycles with extremely linear deflation rates. A manual air release is for immediate pressure drop. A built-in recycle timer can be set to automatically inflate the system in increments of 1 to 999 seconds.

Part #

Description

20NW

Automatic Cuff Inflation Pump

Manual Scanner

The IITC manual scanner is used for making sequential measurements on a group of animals during the tail cuff method test. The scanner can be used in mouse and or rat blood pressure systems that are manually inflated, as well as in semi-automatic systems with an automatic cuff pump. In semi-automatic systems the operator has only to advance the test by turning one single switch on the scanner. Both the electrical parameters of the tail cuff sensor as well as the cuff air are selected with this single switch.

Manual Scanner has the capabilities to test up to 12 animals at a time. The rear panel has the terminated Binary Coded Decimal (BCD) parallel output (voltage free contacts) allows on line data handling equipment to recognize the sequential number of the test position. The scanner accepts 12 air tubing ports in the rear, and 12 plugs from the sensors. The front air ports connect to the pump or inflation bulb and the input plug to an amplifier.

Part #

Description

65-12

Manual Scanner (12 Position)

Animal Warming Chambers

The IITC test chambers offer the perfect uniform test environment when measuring blood pressure noninvasive via the tail cuff method on mice and rats. Offering 1, 3, 6, 12 and 24 channels. The chamber temperature is adjustable and stays at a constant temperature within 1 degree c. at all times via the digitally controlled built in temperature controller. Chambers are ideal for testing from 30 to 40 degrees c.

Temperature is displayed and controlled digitally on the right, exterior side of the warming chamber. Temperature can be adjusted in 2 degree increments. Internal temperature is detected by the built in temperature sensor in the interior chamber wall; allowing precise measurements throughout your study.

All chambers are manufactured of black anodized aluminum and a clear Plexiglas, slide panel door for easy access and viewing of your animals during studies.

Part# 306 warming chamber

Part# 303SC warming chamber

Part#301 warming chamber

A built-in “whisper” fan produces a low level sound that is comforting to the animals. The side panels have been designed with vent holes for air circulation. single animal warming chamber

A superior method of warming when needed for
blood pressure measurements.

Our warming chambers do not supply direct heat in any way as with other methods – heating platforms or blowers that supply heat directly onto animals causing thermostress and the possibility of animal loss are nonexistent with the IITC Life Science method. Supplying a low, consistent, comfortable environment to your animal.

Part #

Description

312

Warming Chamber (12 animals)

306

Warming Chamber (6 animals)

303SCWarming Chamber (3 animals)
301Warming Chamber (1 rat/3 mice)

Tail Cuff (Sensor) Stand for MRI and anesthetized Rat Mouse Blood Pressure

The IITC sensor cuff stand is used to replace the animal restrainer when studies call for animals to be anesthetized, operated on or during MRI mouse and rat blood pressure studies. The sensor stand is used to keep the sensor vertical on the tail. The sensor stand accommodates all five IITC sensors (tail cuffs).

Part #

Description

25

Sensor (Tail Cuff) Sand

SP-1 Accessory Kit for NIBP Blood Pressure Equipment

The IITC Accessory Package contains all necessary consumables for replacement in the IITC Life Science mouse and rat tail cuff blood pressure systems. It is supplied according to the users request for the size of cuff liners and O-rings.

The SP-1 contains:

One pressure gauge with small tubing adapters and manual bulb inflator (this can be used for both calibration and inflation when working with relatively small numbers of animals), 24 small nylon hand screws to mount the sensor to the end plate of the IITC animal restrainers, 50 O-rings that hold cuff liners on the cuff, 100 spare cuff liners (cuff liners and O-rings can be mixed), 50 ft. of Tygon tubing for connecting the cuff air ports to your pressure source.

Part #

Description

SP-1

Accessory Package

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